Best Supplements for Peyronie’s Disease

Peyronie’s disease is a condition characterized by the development of fibrous scar tissue within the penis, leading to curvature, pain, and potential difficulties during sexual activity. While medical interventions are commonly pursued, some individuals explore dietary supplements as a complementary approach to manage symptoms. It’s important to recognize that supplement effectiveness varies person to person, and the supporting scientific evidence is often limited. Consulting with a healthcare provider before starting any new regimen is a smart first step.

What Are the 41 Best Supplements for Peyronie’s Disease?

There’s growing interest in natural ways to support the body in managing Peyronie’s disease. While not all of these supplements are backed by high-level clinical evidence, many are discussed in medical circles and online communities for their potential benefits. Here’s a breakdown of 41 commonly mentioned supplements, along with some insights into how they might help. Always check with your doctor before trying anything new.

List of the Best Supplements for Peyronie’s Disease

PDE-5 Inhibitors: Medications like sildenafil (Viagra) and tadalafil (Cialis) are mainly used for erectile dysfunction, but some research indicates they may also help reduce penile curvature and support healing when used consistently, especially in early-stage Peyronie’s.

Coenzyme Q10 (CoQ10): A powerful antioxidant that helps reduce oxidative stress. Some clinical studies show CoQ10 supplementation may shrink plaque and reduce curvature when used daily over several months.

Vitamin E: A popular choice due to its antioxidant properties. While early studies were hopeful, more recent trials show mixed results. Still, many men continue to use it in combination with other treatments.

L-Arginine: This amino acid helps increase nitric oxide levels in the blood, improving circulation. It’s often used alongside other supplements or medications to support erectile health and potentially ease symptoms.

Acetyl-L-Carnitine: Shown in some studies to reduce penile pain and potentially reduce curvature. Often paired with vitamin E or Cialis for better outcomes.

Omega-3 Fatty Acids: Known for anti-inflammatory benefits. Though not conclusive for Peyronie’s specifically, they’re generally considered helpful for circulation and overall male health.

Potassium Para-Aminobenzoate (Potaba): Previously prescribed to prevent scar tissue buildup. Evidence is inconsistent, and it can cause digestive side effects.

Carnitine: Often confused with Acetyl-L-Carnitine, it supports nerve function and may help with pain. Research is ongoing.

Glucosamine and Chondroitin: Usually used for joint health, but may also support connective tissue repair. Evidence for Peyronie’s is weak.

N-Acetylcysteine (NAC): Helps regulate glutathione, a major antioxidant. Some animal studies suggest it might help reduce fibrosis.

Vitamin D: Far more than a bone health nutrient, vitamin D plays a regulatory role in immune function and fibrosis. A 2020 review published in the International Journal of Molecular Sciences suggests it can suppress TGF-β1, a cytokine involved in scar tissue development. Many men with Peyronie’s are deficient in vitamin D. Getting levels tested and supplementing if needed (typically 2000–5000 IU daily) may help regulate the disease process.

Zinc: Plays a role in tissue repair and immune balance. While not directly studied in Peyronie’s, it’s often included in men’s health formulas.

Curcumin: The active compound in turmeric. Known for reducing inflammation and fibrosis in various conditions. Works best when paired with black pepper extract (piperine).

Resveratrol: Found in grapes and red wine, this antioxidant shows potential in reducing fibrotic activity. Not yet well-studied for Peyronie’s, but promising in general anti-scarring research.

Quercetin: A flavonoid with antioxidant benefits. May reduce oxidative stress that contributes to plaque buildup.

Probiotics: Indirectly beneficial by supporting gut health, which influences inflammation levels body-wide.

Magnesium: Low magnesium has been linked to fibrotic conditions. Supplementing may help, especially if blood levels are low.

Ginkgo Biloba: Used to improve blood flow, which could support oxygenation and healing in penile tissue.

Saw Palmetto: Common in prostate formulas. May support hormone balance, though evidence for Peyronie’s is limited.

Ashwagandha: An adaptogen that supports hormone regulation and stress response. Helpful as part of a holistic approach.

Pycnogenol: This pine bark extract has been shown in combination with L-Arginine to improve erectile function and potentially reduce plaque size.

Ginger: Naturally anti-inflammatory and circulation-boosting. Often included in broader healing protocols.

Cinnamon: Anti-inflammatory, but not directly connected to Peyronie’s in research.

B-Complex Vitamins: Especially B6 and B12, which may help nerve function and energy metabolism.

Grape Seed Extract: Similar to Pycnogenol in benefits. Antioxidant-rich and may support vascular health.

Milk Thistle: Typically used for liver detox, but has anti-inflammatory properties.

Black Seed Oil: Contains thymoquinone, which has shown anti-fibrotic activity in animal models. Anecdotally used for Peyronie’s.

Fenugreek: Sometimes used to boost testosterone. More useful for libido than plaque reduction.

Stinging Nettle: May support hormone balance and reduce mild inflammation.

Serrapeptase: An enzyme thought to break down non-living tissue, including scar tissue. Frequently recommended in fibrotic conditions.

Bromelain: Pineapple-derived enzyme that may reduce inflammation and swelling.

Gotu Kola: Enhances circulation and may support connective tissue repair. Promising in wound-healing studies.

Cayenne Pepper (Capsaicin): Stimulates blood flow and may reduce pain perception. Use cautiously.

MSM (Methylsulfonylmethane): Anti-inflammatory and connective tissue supportive. Common in joint health stacks.

Castor Oil (Topical): Traditionally applied to scarred or inflamed areas. Some men report softening of plaques with regular use.

Silica (Horsetail Extract): May support collagen health and flexibility in connective tissue.

DIM (Diindolylmethane): Helps metabolize estrogen, possibly useful in hormonal imbalances.

SAM-e: Supports methylation and liver function. Some antifibrotic properties shown in liver models.

Colostrum: Rich in growth factors and immune modulators. Anecdotally used to promote healing and recovery.

Bone Broth / Collagen: Natural sources of glycine and proline, supporting overall tissue health and repair.

Below we will discuss some these supplements in more detail:

How CoQ10 Might Help with Peyronie’s Disease

Coenzyme Q10 (CoQ10) is a powerful antioxidant, and while it hasn’t been deeply studied in relation to Peyronie’s disease specifically, its potential to reduce inflammation and oxidative stress makes it worth a look. That said, more research is needed to figure out how effective it really is, and what dosage might work best for Peyronie’s.

Can Vitamin E Reverse Peyronie’s Disease?

Vitamin E has long been known for its antioxidant properties and has actually been used for Peyronie’s disease (PD) since way back in 1948. It’s affordable and widely available, which makes it a go-to supplement. But despite decades of use, multiple controlled studies haven’t shown much promise. In fact, these studies found little to no improvement in pain, plaque size, curvature, or sexual function.
• One 1983 study with 40 PD patients found no significant changes.
• A larger 2007 study involving 236 men also found that vitamin E alone or in combination with other supplements didn’t outperform a placebo.
Still, vitamin E is often paired with other treatments in the hope they might work better together. But keep in mind, high doses can cause nausea, vomiting, diarrhea, and even increase risks of prostate cancer or stroke.

How Much Vitamin E Should You Take?

There’s no official “right dose” for PD. Clinical studies have used anywhere from 400 to 800 IU daily, but always talk to a doctor before starting, especially to avoid potential side effects or drug interactions.

 

L-Arginine and Peyronie’s Disease

L-arginine is a naturally occurring amino acid that helps produce nitric oxide, which relaxes blood vessels and may be linked to collagen production (important because scar tissue is made of collagen). Some early studies suggest L-arginine might help reduce scar tissue and ease penile curvature.

Though generally safe, L-arginine can cause stomach upset, diarrhea, and headaches. If you’re thinking of trying it, check with your healthcare provider, especially if you’re on medications like blood thinners or ED meds.

Acetyl-L-Carnitine for Peyronie’s

Acetyl-L-carnitine is another amino acid supplement that’s shown some promise for treating PD. Besides its use in conditions like Alzheimer’s, depression, and nerve pain, it’s been effective in some PD cases.

A study even found it performed better than tamoxifen at reducing pain and slowing disease progression. It helped decrease curvature and came with fewer side effects. It can be given intravenously or taken orally over several weeks.

However, not everyone sees results—especially older patients. Still, it’s a promising option thanks to its anti-inflammatory effects.

Omega-3 Fatty Acids for Peyronie’s

Omega-3s are well-known for their anti-inflammatory benefits. Though research specifically for PD is limited, these fats could support overall penile health by easing inflammation and possibly reducing pain.

You’ll find omega-3s in fatty fish like salmon, mackerel, sardines, and trout, which are rich in EPA and DHA. Plant-based sources like flaxseeds, chia seeds, and walnuts offer ALA, which the body can convert into EPA and DHA, although not very efficiently.

Even though the evidence isn’t conclusive for PD, omega-3s are a healthy addition to most diets.

Carnitine vs. Acetyl-L-Carnitine

Both are forms of the same compound, but they work a bit differently. L-carnitine helps with energy and fat metabolism, while acetyl-L-carnitine crosses into the brain and may support neurological health. Acetyl-L-carnitine has more evidence supporting its use in PD.

Vitamin D and Peyronie’s Disease

While there’s no strong evidence that vitamin D directly treats PD, one study found that men with PD had lower vitamin D levels compared to those without. Since vitamin D supports immune health and may affect proteins like TGF-β1 (involved in scar tissue formation), maintaining healthy levels might help prevent or manage PD.
Still, more research is needed before we can say for sure. But considering its overall health benefits, it’s a good idea to keep your vitamin D in check.

Zinc and Peyronie’s Disease

Zinc plays key roles in immune function, wound healing, and collagen synthesis—all relevant to PD. It may also regulate enzymes that remodel tissue (matrix metalloproteinases).
Some early studies show it might help reduce plaque and improve curvature and pain, but results are mixed. Too much zinc can cause issues like digestive upset, copper deficiency, and lower immunity, so stick with the recommended dose (11 mg for men).
Zinc-rich foods include oysters, red meat, poultry, beans, nuts, and seeds.

Magnesium and Peyronie’s Disease

There’s limited direct evidence, but magnesium might help with PD by reducing inflammation, supporting collagen synthesis, and helping relax smooth muscles (which improves blood flow).

It’s found in leafy greens, seeds, legumes, and whole grains. Recommended intake is 400-420 mg/day for men. While generally safe, too much magnesium can lead to digestive problems, fatigue, or electrolyte imbalances. It may also interact with some meds.

Vitamin C and Peyronie’s Disease

Vitamin C helps with collagen production, reduces oxidative stress, and has anti-inflammatory effects—all useful in PD. However, research is inconclusive. Some studies show improvement, while others don’t.
It’s not a primary treatment but may be helpful alongside others. High doses can cause digestive upset, kidney stones, or interfere with blood thinners, so it’s best to consult a doctor first.
Vitamin C is abundant in fruits like oranges, strawberries, and veggies like broccoli.

Ginkgo Biloba and Peyronie’s Disease

Ginkgo is an herbal supplement known for improving circulation and offering antioxidant and anti-inflammatory effects. These may be beneficial for PD, though studies are mixed.

Some small studies show improvements in curvature and pain, but more robust research is needed.
Possible side effects include digestive upset, headaches, skin reactions, and interactions with blood thinners or antidepressants. Available in various forms, ginkgo may take weeks to show results.

B-Complex Vitamins and Peyronie’s Disease

B vitamins play many roles in cell metabolism, energy production, and nervous system function. Here’s how they may help with PD:
• B3 (niacin) and B6 (pyridoxine) may reduce inflammation.
• B7 (biotin) and B12 (cobalamin) support circulation.
• B5 (pantothenic acid) aids tissue repair and collagen synthesis.
Though promising, evidence is inconsistent. They’re generally safe, but high doses can cause digestive upset, nerve issues (especially with B6), or skin reactions. Always consult your doctor, especially if you’re on medications.
B vitamins are found in whole grains, legumes, meat, and fish.

Black Seed Oil for Peyronie’s

Black seed oil, derived from Nigella sativa, contains thymoquinone, which has anti-inflammatory and antioxidant effects. These properties could theoretically help with PD, though studies are very limited.
Some early research suggests it may reduce tissue damage and improve circulation. But larger clinical studies are needed to confirm benefits. Side effects are rare but may include stomach upset or mild allergic reactions.

Selenium and Peyronie’s Disease

Selenium is another antioxidant mineral that may help reduce oxidative stress. It might also support collagen production and tissue repair, though studies specific to PD are scarce.

Too much selenium can lead to toxicity (selenosis), causing symptoms like stomach problems, hair/nail changes, or neurological issues. Get it from foods like Brazil nuts, fish, and grains, or use supplements carefully.

Manganese and Peyronie’s Disease

Manganese helps with collagen formation and has antioxidant effects. While not well-studied for PD, one study suggested it might reduce plaque and improve curvature.
Found in whole grains, seeds, nuts, and leafy greens, it’s safe in proper doses (4.4 mg/day for men), but too much can cause neurological issues. Don’t expect it to replace standard treatments like verapamil.

Bee Pollen and Peyronie’s Disease

Bee pollen is nutrient-rich and used in traditional medicine for its anti-inflammatory and antioxidant effects. Limited research suggests it might help reduce plaques when used alongside vitamin E and verapamil.

Early studies show some promise, but larger trials are needed. Side effects are usually mild but can include allergic reactions or stomach upset. Doses used in studies range from 300-600 mg per day.
Bee pollen is not a cure, but it may offer support when used with other treatments. Always consult your doctor before trying it.

Penile Traction Devices:

These are among the most studied non-invasive treatments for Peyronie’s. A 2019 randomized trial of the RestoreX device showed a 31% reduction in curvature and improvements in length with just 30–90 minutes per day. Other devices like Andropenis and Phallosan Forte have also demonstrated benefits when used consistently over 3–6 months. Traction therapy encourages remodeling of scar tissue and is especially effective when started early.

Vacuum Erection Devices (VEDs):

Used primarily for erectile function, but they can also reduce curvature by stretching the tissue and improving blood flow. A 2014 study in Advances in Urology confirmed benefits in penile length and shape. VEDs are often used post-surgery or alongside traction for rehabilitation.

Combination Therapy: Supplements work best when stacked intelligently. For example, CoQ10 + Vitamin E + L-Arginine has shown positive outcomes. Combining these with traction or VED therapy may significantly boost overall results. Some protocols include Pentoxifylline or Cialis under doctor supervision for even better outcomes.

How to Choose the Right Supplement Brand: Choose products with third-party testing, no proprietary blends, and proper dosages. Look for certifications like USP or NSF. Avoid overhyped brands that offer miracle cures without transparency.

How Long Do Supplements Take to Work: Don’t expect overnight results. Most men who see improvements report benefits after 2–3 months, with more meaningful changes after 6 months of consistent use. Pair with lifestyle changes and medical therapies for best results.

What to Avoid If You Have Peyronie’s: Smoking, alcohol abuse, high-sugar diets, and anything that causes trauma to the penis can worsen symptoms or interfere with healing.

Should You See a Doctor Before Starting Supplements? Yes. Especially if you take medications or have other health conditions. Some supplements can interact with drugs or alter hormone levels.

FAQ: Can you cure Peyronie’s with supplements alone? No. Supplements are supportive, not curative.

Are supplements safe with ED medications? Many are, but always check with your doctor.

What if supplements don’t work? They work best when combined with physical therapies like traction, injections, or even surgery if needed. Don’t give up — results often take time.