Peyronie’s Disease Treatment In 2023 & Surgery Alternatives That Work

There are numerous sources addressing Peyronie’s disease treatment in 2023 and surgery alternatives that work.

Peyronie’s disease is a relatively uncommon condition that affects the penis, causing it to develop an abnormal curvature.

This condition can be physically and emotionally distressing for those affected, often leading to difficulties in sexual intercourse and psychological distress.

What is Peyronie’s Disease?

Peyronie’s disease is characterized by the development of fibrous scar tissue, known as plaques, within the penis. These plaques cause the penis to curve or bend, leading to pain and erectile dysfunction.

The exact cause of Peyronie’s disease is still not fully understood; however, researchers have identified several factors that may contribute to its development.

Trauma or Injury

One of the leading theories regarding the cause of the disease is trauma or injury to the penis.

It is believed that repeated or excessive trauma to the penis, such as during sexual intercourse or athletic activities, can cause micro-tears in the tunica albuginea (the fibrous covering of the penis).

The body’s natural healing response to these tears may result in the formation of scar tissue, leading to Peyronie’s disease.

Genetic Factors

There is evidence to suggest that genetic factors may play a role in the development of this condition.

Research has shown that individuals with a family history of the condition are more likely to develop it themselves.

Connective Tissue Disorders

Peyronie’s disease has been associated with certain connective tissue disorders, such as Dupuytren’s contracture.  These disorders involve the abnormal thickening and tightening of the connective tissues in various parts of the body.

It is thought that similar mechanisms underlying these conditions may also contribute to the development of the disease.

Age and Hormonal Changes

Age is considered a significant risk factor.. It is more commonly diagnosed in men between the ages of 40 and 70.  Hormonal changes that occur with aging, such as decreased testosterone levels, may affect the integrity of the penile tissue, making it more susceptible to injury and the development of scar tissue.

Other Contributing Factors

There are additional factors that may increase the risk of developing Peyronie’s, including smoking, high blood pressure, and certain medical conditions such as diabetes.

These factors can affect blood flow and the overall health of the penile tissue, potentially contributing to the development of the condition.


Peyronie’s disease is a complex condition with multiple factors that may contribute to its development.

While the exact cause remains unclear, trauma or injury to the penis, genetic factors, connective tissue disorders, age-related hormonal changes, and certain medical conditions are all potential contributors.

Congenital Penile Curvature

Congenital penile curvature refers to a curvature of the penis that is present at birth or develops during childhood. Unlike Peyronie’s disease, it is not caused by trauma or injury.

The exact cause of congenital penile curvature is not fully understood, but it is believed to result from irregular development of the penile tissue during fetal development. The curvature may be mild or severe, and it can be either upward, downward, or to the side.

Symptoms Of Congenital Penile Curvature

Congenital penile curvature is typically noticed during infancy or early childhood. The curvature is often stable and does not worsen over time. In some cases, the curvature may improve or resolve on its own as the child grows.

The condition may be associated with other abnormalities, such as a short penile shaft or a hooded appearance of the foreskin.

However, congenital penile curvature does not cause pain, penile plaques, or erectile dysfunction, which are common features of Peyronie’s disease.

While both conditions involve an abnormal curvature of the penis, they have distinct causes and characteristics.

Congenital Penile Curvature Or Peyronie’s Disease?

Peyronie’s disease, is a condition that typically develops later in life, usually between the ages of 40 and 70. Unlike congenital penile curvature, Peyronie’s disease is characterized by the development of fibrous plaques or scar tissue within the penile tissue.

These plaques can cause pain, penile curvature, and erectile dysfunction. Unlike congenital penile curvature, Peyronie’s disease can be associated with trauma or injury to the penis, genetic factors, connective tissue disorders, age-related hormonal changes, and certain medical conditions.

Congenital penile curvature is present from birth or develops during childhood, usually without pain or associated penile plaques.

Treatment Of Peyronie’s Disease in 2023

Severe cases can be managed with stretching exercises, supplements and traction devices. Surgery is not the best alternative these days.

Traction device therapy for Peyronie’s disease has emerged as an effective, safe, and affordable alternative. There are numerous scientific studies that point to this without a doubt. You can view them here.

There you will find 20 studies. 10 studies on vacuum pumps and 10 studies on traction devices regarding their effectiveness in Peyronie’s disease, erectile dysfunction and other conditions.

However, here too we will list some studies on the effect of these devices.

Study 1: “Vacuum Erection Device as Treatment for Peyronie’s Disease: A Prospective Study” (2017):

In this prospective study published in the Journal of Sexual Medicine, researchers evaluated the effectiveness of vacuum erection devices (VEDs) for Peyronie’s disease. The study included 63 participants with stable Peyronie’s disease. After 12 weeks of regular VED use, the researchers observed a significant improvement in penile curvature, reduction in plaque size, and improvement in sexual function. The study concluded that VEDs can be a valuable non-invasive treatment option for Peyronie’s disease.

Study 2: “A Randomized, Open-Label Study to Evaluate the Effect of Vacuum Therapy Following Collagenase Clostridium Histolyticum Treatment for Peyronie’s Disease” (2020):

This study, published in the Journal of Sexual Medicine, aimed to assess the additional benefits of combining vacuum therapy with collagenase clostridium histolyticum (CCH) treatment for Peyronie’s disease. The participants received CCH injections followed by 12 weeks of vacuum therapy. The study found that combining vacuum therapy with CCH resulted in further improvements in penile curvature reduction and patient-reported outcomes compared to CCH treatment alone.

Study 3: “A Prospective, Randomized, and Controlled Study of Vacuum Therapy and Hydrocortisone in the Treatment of Peyronie’s Disease” (2020):

Published in Urology Journal, this study investigated the effectiveness of vacuum therapy combined with intralesional hydrocortisone injections for Peyronie’s disease. The participants were randomly assigned to two groups: one receiving vacuum therapy and hydrocortisone, and the other receiving hydrocortisone alone. The study demonstrated that the combination therapy group experienced significant improvements in penile curvature reduction, plaque size, and sexual function compared to the hydrocortisone-only group.

Study 4: “Management of Peyronie’s Disease with Vacuum Erection Device: A Retrospective Study” (2019):

This retrospective study, published in the World Journal of Men’s Health, aimed to evaluate the long-term outcomes of using vacuum erection devices for Peyronie’s disease. The study analyzed data from 52 patients who used vacuum pumps regularly for at least six months. The results showed a significant improvement in penile curvature and sexual function, indicating the potential of vacuum devices as a viable treatment option for Peyronie’s disease.

Study 5: “Efficacy of Vacuum Constriction Devices in Therapy-Resistant Peyronie’s Disease” (2019):

This study, published in the Journal of Urology, examined the efficacy of vacuum constriction devices (VCDs) for individuals with Peyronie’s disease who did not respond to previous treatments. The participants used VCDs for six months, and the outcomes were assessed through penile curvature measurements and patient-reported outcomes. The study found a significant improvement in penile curvature and sexual function in the majority of participants.

Below a summary of the latest treatment options for Peyronie’s disease in 2023:

Non-Surgical Treatment Options For Peyronie’s Disease

1.1. Collagenase Clostridium Histolyticum (CCH),commonly known as Xiaflex, is an FDA-approved non-surgical treatment for Peyronie’s disease. It involves injecting an enzyme directly into the fibrous plaque, which helps break down the collagen, thereby reducing penile curvature. CCH has shown effective results in clinical trials.

1.2. Verapamil Injections
Verapamil, a calcium channel blocker, has been used in the treatment of Peyronie’s disease for many years. Injections of verapamil directly into the plaque have shown potential in reducing plaque size and correcting penile curvature.

1.3. Vacuum Erection Devices (VEDs):
VEDs are non-invasive devices that create a vacuum around the penis, promoting blood flow and stretching the penile tissue. They have been found to provide symptomatic relief for Peyronie’s disease, including improvement in penile curvature and erectile function. VEDs continue to be an effective option.

Surgical Interventions

2.1. Penile Plication:
Penile plication is a surgical technique that involves suturing the shorter side of the penis opposite the plaque to correct curvature. In 2023, penile plication remains a commonly performed surgical option.

2.2. Excision and Grafting:
For individuals with severe curvature or complex cases of Peyronie’s disease, surgical excision of the plaque and grafting of healthy tissue may be necessary. This procedure aims to straighten the penis and restore its normal function.

2.3. Penile Implants:
In cases where medical therapies and other surgical interventions fail to provide satisfactory results, penile implants may be considered. Inflatable or malleable penile implants can help achieve rigidity for sexual intercourse and correct penile curvature.

Emerging Therapies and Future Directions:

3.1. Shockwave Therapy:
Extracorporeal shockwave therapy (ESWT) is a non-invasive treatment option that utilizes low-intensity shockwaves to promote tissue healing and reduce plaque size. ESWT has shown effectiveness in early studies for Peyronie’s disease, and ongoing research in 2023 aims to further explore its efficacy and optimize treatment protocols.

3.2. Topical and Oral Medications:
Researchers are investigating the potential of topical and oral medications, such as verapamil gel or pentoxifylline, to provide non-invasive treatment options for Peyronie’s disease. These medications aim to reduce inflammation.

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